Diclofenac Injection

DICLOmera is an injectable Diclofenac Sodium, a derivative of phenylacetic acid, and is a concentrated preparation. Being a non-selective blocker of the cyclooxygenase (COX-1 and COX-2) enzymes, it stops the synthesis of prostaglandins, the chemical messengers that cause pain and inflammatory swelling. It is developed using the Diclofenac Sodium (25 mg/surgically clean), a non-steroidal anti-inflammatory medication (NSAID), created to be used in those instances when an oral form of medication is not sufficient or effective. Its injectable form guarantees fast absorption into the system, which produces peak plasma levels much quicker than conventional tablets, and as such, the injectable form is a vital resource in acute care environments.

Composition:
Each 1 ml ampoule contains:

• Diclofenac Sodium 25 mg
  (Note: 2.5 mg appears to be a typo or unusually low; standard strength is 25 mg/ml)

Therapeutic Class: Non-Steroidal Anti-Inflammatory Drug (NSAID)
(Used for the relief of pain and inflammation in conditions such as musculoskeletal disorders, postoperative pain, and arthritis)

Medical Uses

DICLOmera is used in the short-term treatment of acute painful conditions in which there is a need to attain effect at a fast rate:

• Post surgery Recovery: The management of moderate to severe pain after surgery.
• Acute Musculoskeletal Disorders: Relieving serious strains, sprains, and low back pain.
• Arthritic Flare-ups: Management of acute rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis.
• Renal and Biliary Colic: Relaxing the severe intermittent pain in the kidneys or gallbladder stones.
• Gouty Attacks: Lightning response of reducing the local inflammation and the glass-like pains in the joints.

Directions to Use

DICLOmera should be administered by a qualified medical personnel only during Deep Intramuscular (IM) Injection to the gluteal muscle. It is essential to make the deep injection approach and ensure rotation of sites in case of another dosage requirement, as per the necessary doses, to avoid the risk of local tissue destruction or injection site necrosis. Intravenous (IV) Infusion may be used in some clinical cases when it is diluted with a compatible solution such as 0.9% Sodium Chloride, usually in a period of 30-120 minutes.

Precautions

Cardiovascular Health: NSAIDs might be associated with the risk of severe cardiovascular thrombotic events; the lowest possible dose should be used in the shortest possible duration.
Gastrointestinal Integrity Patients with a history of peptic ulcers or GI bleeding need to be observed.
Hydration: Make sure that the patient is adequately hydrated before administration to prevent damage to the kidneys.

Possible Side Effects

Healthcare professionals recommend this injectable medication due to its safety and high potency to provide effective therapeutic results. Though in a very few cases, it has been observed that a few people have registered some possible side effects. These side effects are rare, and it is not intended to happen to every patient, but in case you face any of these symptoms, then wait for a few hours (most of the side effects are temporary and normalize after some time). If it becomes severe or causes any serious condition, then seek medical help immediately.

• Local: local pain, redness, or induration of the injection location.
• Gastrointestinal: Nausea, stomach ache, or dyspepsia.
• Neurological: Lightheadedness or terminal headache immediately after taking.
• Hypersensitivity: Extremely infrequent skin rash or bronchospasm.

Frequently Asked Questions

Q: What is the difference between DICLOmera and normal oral Diclofenac tablets?

A: DICLOmera does not undergo the first-pass through the liver, which makes it much quicker in relieving pain, which is essential with acute trauma, or through post-surgery healing.

Q: Does DICLOmera cause any problems with patients who had hypertension in the past?

A: Diclofenac may lead to sodium retention and thus raise the blood pressure, and thus constant checkups are always advisable when using it.

Q: Why is the formula of Diclofenac by Numera Life Sciences considered remarkable over other brands' injectables of the same composition?

A: Numera Life Sciences employs higher-order stabilization technology to maintain the solution in a stabilized pH to minimize the stinging effect commonly felt when injecting NSAIDs.

Q: Is it possible to use DICLOmera with any other painkillers through the same syringe?

A: No, a combination of DICLOmera with other drugs may result in a chemical precipitate. It is to be given as a single injection to uphold its pharmacological activity.

Q: What is the duration of action of the analgesic effect of one dose of DICLOmera?

A: The therapeutic effect lasts probably between 6 and 8 hours, with the change depending on the condition of the patient and their metabolism rate.