Piperacillin + Tazobactam Injection

Pipracillin + Tazobactam Injection is a high-potency injectable that belongs to a therapeutic class of broad-spectrum Penicillin Antibiotic with β-lactamase Inhibitor. It is commonly prescribed for the treatment of moderate to severe bacterial infections, including intra-abdominal, respiratory, urinary tract, and skin infections. Its formulation includes Piperacillin (4 g) and Tazobactam (0.5 g), which work by inhibiting the synthesis of the bacterial cell wall, leading to the destruction of the pathogen. With its dual-action of a powerful extended-spectrum penicillin with a protective enzyme inhibitor. The  Tazobactam is included in its composition, which helps to make a biological shield that deactivates these enzymes and allows the Piperacillin to perform its therapeutic function without any interference.

Composition:
Each vial contains:

• Piperacillin 4 g
• Tazobactam 0.5 g

Therapeutic Class: Broad-Spectrum Penicillin Antibiotic with β-lactamase Inhibitor
(Indicated for the treatment of moderate to severe bacterial infections, including intra-abdominal, respiratory, urinary tract, and skin infections)

Medical Uses

PIPrax-T injectable medication is classified as a Broad-Spectrum Penicillin Antibiotic, which is indicated for managing moderate to severe systemic infections, including:

• Intra-abdominal Infections
• Respiratory Tract Infections
• Skin and Soft Tissue Infections
• Urinary Tract Infections (UTIs)
• Febrile Neutropenia

Directions to Use

• It is strictly directed to administer this injectable medication only through Intravenous (IV) infusion or slow IV injection.
• It must be reconstituted by a healthcare professional using a compatible diluent (such as 0.9% Sodium Chloride or Sterile Water for Injection).
• The dosage and frequency would be strictly prescribed by the clinician based on the patient’s weight, age, and renal function. 
• Generally, the infusions are administered over a period of 30 minutes.

Precautions

• Patients with a history of hypersensitivity to penicillins, cephalosporins, or β-lactamase inhibitors must inform their doctor.
• Dose adjustments are necessary for patients with kidney impairment to prevent accumulation.
• As this product contains sodium, it should be monitored in patients requiring salt restriction.
• High doses in patients with renal failure may increase the risk of seizures.

Possible Side Effects

While generally well-tolerated, some patients may experience:

• Gastrointestinal: Diarrhea, nausea, or constipation.
• Dermatological: Rash or itching at the injection site.
• Blood Chemistry: Occasional fluctuations in liver enzymes or white blood cell counts.
• Secondary Infection: Long-term use may lead to oral thrush or vaginal yeast infections.

Frequently Asked Questions

Q: What are the benefits of adding Tazobactam to the Piperacillin in PIPrax-T?

A: Tazoactam acts as a decoy that neutralizes the β-lactamase enzymes, which helps to prevent bacteria from destroying Piperacillin. 

Q: Can a patient with a common cold or flu take the PIPrax injection offered by Numera Life Sciences?

A: No, it isstrictly prohibited to use this injection for bacterial infections as PIPrax does not affect viral pathogens that cause common cold or influenza.

Q: Does Numera Life Sciences have a certification from the recognized bodiesfor sterile manufacturing?

A: Yes, Numera Life Sciences adheres to stringent ISO and GMP standards that enable us to deliver high-potency injectables like PIPrax-T injection. 

Q: What does the role of PIPrax injection play in hospital-acquired pneumonia?

A: PIPrax has a broad-spectrum nature that covers Pseudomonas aeruginosa, which is a common hospital pathogen. It is the first-line medication used for severe, healthcare-associated respiratory infections.

Q: Does the presence of sodium content in the formulation of PIPrax injection affect patients with heart-related problems?

A: Each vial of PIPrax injection contains a specific amount of sodium in its composition. It is advised that patients with heart-related problems use this injectable only under medical supervision and that it be closely monitored by the doctor.

Q: What process does Numer Life Sciences follow to ensure the stability of this injection?

A: Numera Life Sciences uses a sealed medical-grade glass to prevent moisture ingress and to ensure the antibiotic remains potent until its expiration date.